Increased endogenous H 2 S generation by CBS , CSE and 3 MST 1 gene therapy improves ex vivo renovascular relaxation in 2 hyperhomocysteinemia 3 4
نویسندگان
چکیده
hyperhomocysteinemia 3 4 Utpal Sen, Pushpakumar B. Sathnur*, Sourav Kundu*, Srikanth Givvimani, Denise M. 5 Coley, Paras K. Mishra, Natia Qipshidze, Neetu Tyagi, Naira Metreveli and Suresh C. 6 Tyagi 7 8 Department of Physiology and Biophysics, University of Louisville School of Medicine, 9 Louisville, Kentucky 10 11 12 13 14 15 16 17 Running title: H2S improves vascular function in HHcy 18 19 20 *These authors contributed equally 21 22 23 Address correspondence to: 24 Utpal Sen, Ph.D. 25 500 South Preston St, A-1115 26 University of Louisville 27 Louisville, KY-40202 28 Phone: 502-852-2030 29 Fax: 502-852-6239 30 Email: [email protected] 31 Articles in PresS. Am J Physiol Cell Physiol (April 18, 2012). doi:10.1152/ajpcell.00398.2011
منابع مشابه
The H2S Donor NaHS Changes the Expression Pattern of H2S-Producing Enzymes after Myocardial Infarction
Aims. To examine the expression patterns of hydrogen sulphide- (H2S-) producing enzymes in ischaemic heart tissue and plasma levels of H2S after 2 weeks of NaHS treatment after myocardial infarction (MI) and to clarify the role of endogenous H2S in the MI process. Results. After MI surgery, 2 weeks of treatment with the H2S donor NaHS alleviated ischaemic injury. Meanwhile, in ischemia myocardi...
متن کاملCardiovascular disease and resuscitated septic shock lead to the downregulation of the H2S-producing enzyme cystathionine-γ-lyase in the porcine coronary artery
BACKGROUND Downregulation of the hydrogen sulfide (H2S)-producing enzymes cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), and/or 3-mercaptopyruvate sulfurtransferase (3-MST) is associated with chronic cardiovascular pathologies. Nevertheless, equivocal data are available on both the expression and function of these enzymes in coronary arteries (CA). We recently reported that athero...
متن کاملInducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is H2S a novel cytoprotective mediator in the inflamed joint?
Hydrogen sulfide (H(2)S) has recently been proposed as an endogenous mediator of inflammation and is present in human synovial fluid. This study determined whether primary human articular chondrocytes (HACs) and mesenchymal progenitor cells (MPCs) could synthesize H(2)S in response to pro-inflammatory cytokines relevant to human arthropathies, and to determine the cellular responses to endogeno...
متن کاملEndogenously produced hydrogen sulfide supports tumor cell growth and proliferation
Hydrogen sulfide (H 2 S) is an endogenous gaseous biological mediator. In the cardiovascular system, it acts as a vasodilator, proangiogenic hormone, and cardioprotectant, while in the nervous system, it functions as a neurotransmitter and neuroprotectant. Our interest in the role of H 2 S in cancer biology was initially triggered by our observations in endothelial cells showing that the proang...
متن کاملEffect of Thyrotoxicosis on Gene Expression of Hydrogen Sulfide-producing Enzymes in Epididymal Adipose Tissue of Male Rats
Introduction: Thyroid hormones are involved in the regulation of hydrogen sulfide (H2S) biosynthesis. The aim of this study is to determine effects of thyrotoxicosis on H2S levels and mRNA expression of cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST) in the adipose tissue of rat. Materials and Methods: Male rats were divided into the ...
متن کامل